lv thrombus apixaban | apixaban dose for Lv thrombus lv thrombus apixaban Keywords: Apixaban, direct oral anticoagulants, DOACs, left ventricular thrombus, Rivaroxaban, thrombolysis. 1. BACKGROUND. Left ventricular thrombus (LVT) is a common complication following acute myocardial infarction (AMI) with potential for significant morbidity and mortality.
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0 · guidelines for Lv thrombus anticoagulation
1 · apixaban vs warfarin Lv thrombus
2 · apixaban for mural thrombus
3 · apixaban dose for Lv thrombus
4 · apixaban and warfarin difference
5 · Lv thrombus treatment guidelines nhs
6 · Lv thrombus treatment guidelines
7 · Lv thrombus prevention guidelines
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Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin.
Studies suggest an increased risk of thromboembolism in patients with LV . Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin.
Studies suggest an increased risk of thromboembolism in patients with LV noncompaction related to LV thrombus formation in the deep intertrabecular recesses. 72 A Heart Rhythm Society expert consensus statement recommends that anticoagulation may be reasonable with LV noncompaction and LV dysfunction (Class of Recommendation IIb; Level .
Of the 514 patients with LV thrombi, 300 received warfarin, while 185 received DOAC therapy. DOAC use was most commonly apixaban (141/185, 76.2%) or rivaroxaban (46/185, 24.9%). Median follow-up was 351 days (interquartile range, [IQR], 51-866 days).Keywords: Apixaban, direct oral anticoagulants, DOACs, left ventricular thrombus, Rivaroxaban, thrombolysis. 1. BACKGROUND. Left ventricular thrombus (LVT) is a common complication following acute myocardial infarction (AMI) with potential for significant morbidity and mortality. Current guidelines recommend anticoagulation with a vitamin K antagonist to treat left ventricular (LV) thrombus after myocardial infarction (MI). Data on the use of direct oral anticoagulants (DOACs) in this setting are limited. The aim of the study was to assess the efficacy of apixaban vs. warfarin in treating LV thrombus after MI.Direct oral anticoagulants are frequently used to treat post-myocardial infarction (MI) left ventricular thrombus (LVT). This study was conducted to evaluate the efficacy and safety of use of apixaban, compared to the standard warfarin therapy, in post-MI LVT.
The study is a prospective, randomized, multi-center open label trial comparing apixaban (at a dose of 5 mg twice daily) with s.c enoxaparin 1mg/kg BID followed by dose-adjusted warfarin to achieve a target international normalized ratio (INR) of 2.0 to 3.0 for 3 months in patients with LV thrombus detected by echocardiography 3 to 14 days . Left ventricular thrombus (LVT) is not uncommon and pose a risk of systemic embolism, which can be mitigated by adequate anticoagulation. Direct oral anticoagulants (DOACs) are increasingly being used as alternatives to warfarin for anticoagulation, but their efficacy and safety profile has been debated.
The advent of reperfusion therapy and the widespread use of primary percutaneous coronary intervention (PCI) have markedly reduced the incidence of post–myocardial infarction (MI) left ventricular thrombus (LVT) over the last decades (1–3).
guidelines for Lv thrombus anticoagulation
apixaban vs warfarin Lv thrombus
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The American and European guidelines recommend oral anticoagulant therapy with warfarin with varying durations from 3-6 months. However, there are no prospective trials comparing warfarin and direct oral anticoagulants (DOACs) as anticoagulation in the treatment of LV thrombus. Our results suggest that apixaban is non-inferior to warfarin for treatment of patients with LV thrombus after acute MI with a 20% non-inferiority margin. Studies suggest an increased risk of thromboembolism in patients with LV noncompaction related to LV thrombus formation in the deep intertrabecular recesses. 72 A Heart Rhythm Society expert consensus statement recommends that anticoagulation may be reasonable with LV noncompaction and LV dysfunction (Class of Recommendation IIb; Level .
Of the 514 patients with LV thrombi, 300 received warfarin, while 185 received DOAC therapy. DOAC use was most commonly apixaban (141/185, 76.2%) or rivaroxaban (46/185, 24.9%). Median follow-up was 351 days (interquartile range, [IQR], 51-866 days).Keywords: Apixaban, direct oral anticoagulants, DOACs, left ventricular thrombus, Rivaroxaban, thrombolysis. 1. BACKGROUND. Left ventricular thrombus (LVT) is a common complication following acute myocardial infarction (AMI) with potential for significant morbidity and mortality. Current guidelines recommend anticoagulation with a vitamin K antagonist to treat left ventricular (LV) thrombus after myocardial infarction (MI). Data on the use of direct oral anticoagulants (DOACs) in this setting are limited. The aim of the study was to assess the efficacy of apixaban vs. warfarin in treating LV thrombus after MI.
Direct oral anticoagulants are frequently used to treat post-myocardial infarction (MI) left ventricular thrombus (LVT). This study was conducted to evaluate the efficacy and safety of use of apixaban, compared to the standard warfarin therapy, in post-MI LVT. The study is a prospective, randomized, multi-center open label trial comparing apixaban (at a dose of 5 mg twice daily) with s.c enoxaparin 1mg/kg BID followed by dose-adjusted warfarin to achieve a target international normalized ratio (INR) of 2.0 to 3.0 for 3 months in patients with LV thrombus detected by echocardiography 3 to 14 days .
Left ventricular thrombus (LVT) is not uncommon and pose a risk of systemic embolism, which can be mitigated by adequate anticoagulation. Direct oral anticoagulants (DOACs) are increasingly being used as alternatives to warfarin for anticoagulation, but their efficacy and safety profile has been debated.
The advent of reperfusion therapy and the widespread use of primary percutaneous coronary intervention (PCI) have markedly reduced the incidence of post–myocardial infarction (MI) left ventricular thrombus (LVT) over the last decades (1–3).
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apixaban for mural thrombus
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lv thrombus apixaban|apixaban dose for Lv thrombus
